منابع مشابه
Potassium channel regulation.
The sulphonylurea receptor (SUR) is a member of the ATP-binding cassette (ABC) family of membrane proteins. It functions as the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which comprises SUR and Kir6.x proteins. Here, we review data demonstrating functional differences between the two nucleotide binding domains (NBDs) of SUR1. In addition, to explain the structural basis ...
متن کاملSensory Plasticity: Seasonal Regulation of Hearing by a Potassium Channel
Animals may vary in their responsiveness to sensory cues seasonally. The transcriptional regulation of a potassium channel in the hearing organ of a fish explains its seasonally varying sensitivity to acoustic frequencies in its courtship vocalization.
متن کاملPotassium Channel Regulation in Developmental Myelinogenesis Schwann Cells During Early
The presence of neuronal-like, voltage-gated ion channels on glia has raised questions concerning their physiological roles. Insights into glial channel function can be gained by examining regulation of channel expression during axoglial interactions. We examine the regulation of Schwann cell potassium channels in developing sciatic nerves of newborn rats when myelin is first laid down. During ...
متن کاملMechanisms contributing to myocardial potassium channel diversity, regulation and remodeling.
In the mammalian heart, multiple types of K(+) channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K(+) channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K(+) channel diversit...
متن کاملRegulation of Kv1.2 Potassium Channel Trafficking by Adenylate Cyclase: Mechanisms
Specific Aims By modulating action potential firing patterns and neurotransmitter release dynamics throughout the brain, the Shaker family voltage-gated potassium channel Kv1.2 is a critical regulator of neurophysiology. However, mechanisms by which neuronal Kv1.2 may be regulated are poorly understood. In heterologous expression systems, Kv1.2 is regulated by endocytic trafficking, and both ad...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2003
ISSN: 1469-221X,1469-3178
DOI: 10.1038/sj.embor.embor7400003